Actors from a company that embarked on a two-year Hamlet world tour in 2014, playing to more than 100,000 people in 197 countries, put on a special performance for the president.
Obama watched actors perform various scenes from the tragedy, including the famous "To be, or not to be" soliloquy from the fictional Danish prince.
The president stood in the open-air theatre watching intently, at times swaying back and forth on his feet to the music.
He clapped loudly following the show and joined actors on the stage afterwards.
"Let me shake hands with everyone. That was wonderful. I don't want it to stop," Obama said.
The performers returned to London on Friday from their world tour, and will perform their four final shows at the Globe this weekend.
Obama was also given a tour of the playhouse by Patrick Spottiswoode, director of director of education at the theatre.
"You're doing a great job," he told Spottiswoode.
The Globe was rebuilt close to its original site and stages authentic period performances of plays by Shakespeare and others.
The theatre's artistic director Dominic Dromgoole said it was "an honour" to host the president -- whose 2008 campaign slogan, he added, had inspired the Hamlet world tour.
"At the end of an extraordinary journey all around the world, it is great to return home to the Globe and to be able to perform a few scenes and to be welcomed back by President Barack Obama," said Dromgoole.
"The spirit of 'Yes we can' has informed the entire tour and it's an honour to meet the man who coined the phrase, and who exemplifies its spirit."
William Shakespeare's hometown of Stratford-upon-Avon on Saturday leads the global celebrations to mark four centuries since his death, with star-studded plays, concerts and parades.
Focal points for the celebrations include Shakespeare's family home in Stratford, where it is assumed he was born in 1564, and the Holy Trinity Church, where he was buried.
From Warsaw, to Dubai and Las Vegas, Shakespeare's work will also be playing to packed houses to mark the occasion, highlighting the international appeal of the English language's leading playwright.
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Obama watched actors perform various scenes from the tragedy, including the famous "To be, or not to be" soliloquy from the fictional Danish prince.
The president stood in the open-air theatre watching intently, at times swaying back and forth on his feet to the music.
He clapped loudly following the show and joined actors on the stage afterwards.
"Let me shake hands with everyone. That was wonderful. I don't want it to stop," Obama said.
The performers returned to London on Friday from their world tour, and will perform their four final shows at the Globe this weekend.
Obama was also given a tour of the playhouse by Patrick Spottiswoode, director of director of education at the theatre.
"You're doing a great job," he told Spottiswoode.
The Globe was rebuilt close to its original site and stages authentic period performances of plays by Shakespeare and others.
The theatre's artistic director Dominic Dromgoole said it was "an honour" to host the president -- whose 2008 campaign slogan, he added, had inspired the Hamlet world tour.
"At the end of an extraordinary journey all around the world, it is great to return home to the Globe and to be able to perform a few scenes and to be welcomed back by President Barack Obama," said Dromgoole.
"The spirit of 'Yes we can' has informed the entire tour and it's an honour to meet the man who coined the phrase, and who exemplifies its spirit."
William Shakespeare's hometown of Stratford-upon-Avon on Saturday leads the global celebrations to mark four centuries since his death, with star-studded plays, concerts and parades.
Focal points for the celebrations include Shakespeare's family home in Stratford, where it is assumed he was born in 1564, and the Holy Trinity Church, where he was buried.
From Warsaw, to Dubai and Las Vegas, Shakespeare's work will also be playing to packed houses to mark the occasion, highlighting the international appeal of the English language's leading playwright.
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